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vitamin K-dependent protein Z (PROZ)
Function:
- appears to assist hemostasis by binding thrombin & promoting its association with phospholipid vesicles
- the iron & 2-oxoglutarate dependent 3-hydroxylation of aspartate & asparagine is (R) stereospecific within EGF domains
Structure:
- belongs to the peptidase S1 family
- contains 2 EGF-like domains
- contains 1 Gla (gamma-carboxy-glutamate) domain
- contains 1 peptidase S1 domain
Compartment: secreted
Alternative splicing: named isoforms=2
Expression: plasma
Note:
- although homologous with vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues & has no enzymatic activity
General
glycoprotein
secreted peptide
Properties
SIZE: entity length = 400 aa
MW = 45 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
Gla {41-86}
MOTIF: cysteine residue {C58}
MODIFICATION: cysteine residue {C63}
cysteine residue {C63}
MODIFICATION: cysteine residue {C58}
EGF domain {87-123}
MOTIF: cysteine residue {C91}
MODIFICATION: cysteine residue {C102}
Ser glycosylation site {S93}
cysteine residue {C96}
MODIFICATION: cysteine residue {C111}
N-glycosylation site {N99}
cysteine residue {C102}
MODIFICATION: cysteine residue {C91}
cysteine residue {C111}
MODIFICATION: cysteine residue {C96}
cysteine residue {C113}
MODIFICATION: cysteine residue {C122}
cysteine residue {C122}
MODIFICATION: cysteine residue {C113}
EGF domain {125-166}
MOTIF: cysteine residue {C129}
MODIFICATION: cysteine residue {C141}
cysteine residue {C137}
MODIFICATION: cysteine residue {C150}
cysteine residue {C141}
MODIFICATION: cysteine residue {C129}
cysteine residue {C150}
MODIFICATION: cysteine residue {C137}
cysteine residue {C152}
MODIFICATION: cysteine residue {C165}
cysteine residue {C165}
MODIFICATION: cysteine residue {C152}
S1 domain {175-400}
MOTIF: cysteine residue {C203}
MODIFICATION: cysteine residue {C219}
cysteine residue {C219}
MODIFICATION: cysteine residue {C203}
N-glycosylation site {N225}
N-glycosylation site {N233}
N-glycosylation site {N306}
cysteine residue {C327}
MODIFICATION: cysteine residue {C341}
N-glycosylation site {N332}
cysteine residue {C341}
MODIFICATION: cysteine residue {C327}
Database Correlations
OMIM 176895
UniProt P22891
PFAM correlations
Entrez Gene 8858
Kegg hsa:8858
References
- UniProt :accession P22891
- SeattleSNPs
http://pga.gs.washington.edu/data/proz/