protein very KIND (kinase non-catalytic C-lobe domain-containing protein 1, KIND domain-containing protein 1, Ras-GEF domain-containing family member 2, cerebral protein 9, KNDC1, C10orf23, KIAA1768, RASGEF2, VKIND, hucep-9)

Function: probable guanine nucleotide exchange factor (GEF) Structure: - contains 2 KIND domains - contains 1 N-terminal Ras-GEF domain - contains 1 Ras-GEF domain Alternative splicing: named isoforms=6 Expression: expressed specifically in the cerebral cortex

General

guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS) phosphoprotein

Properties

SIZE: entity length = 1749 aa MW = 191 kD MOTIF: KIND 1 {66-217} KIND 2 {444-608} proline-rich region SITE: 724-885 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S982} coiled coil {1133-1190} guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 1246-1371 guanine nucleotide exchange domain NAME: guanine nucleotide exchange domain SITE: 1468-1719

Database Correlations

UniProt Q76NI1 PFAM correlations

References

UniProt :accession Q76NI1