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receptor-type tyrosine-protein phosphatase S; R-PTP-S; receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma (PTPRS)
Function:
- interacts with LAR-interacting protein LIP.1
- undergoes 'ectodomain shedding'
- interacts with PPFIA1, PPFIA2 & PPFIA3
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 2A subfamily
- contains 8 fibronectin F3 modules
- contains 3 Ig-like C2-type domains
- contains 2 tyrosine-protein phosphatase domains
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing:
- named isoforms=7
- additional isoforms seem to exist
Expression:
- expressed in most tissues
- not expressed in placenta & liver
General
glycoprotein
receptor
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1948 aa
MW = 217 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-29}
immunoglobulin superfamily domain {33-123}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C107}
cysteine residue {C107}
MODIFICATION: cysteine residue {C54}
immunoglobulin superfamily domain {135-233}
MOTIF: cysteine residue {C156}
MODIFICATION: cysteine residue {C216}
cysteine residue {C216}
MODIFICATION: cysteine residue {C156}
immunoglobulin superfamily domain {245-327}
MOTIF: N-glycosylation site {N263}
cysteine residue {C266}
MODIFICATION: cysteine residue {C311}
N-glycosylation site {N308}
cysteine residue {C311}
MODIFICATION: cysteine residue {C266}
fibronectin type III domain or F3 module {332-420}
fibronectin type III domain or F3 module {426-520}
fibronectin type III domain or F3 module {525-614}
fibronectin type III domain or F3 module {618-715}
MOTIF: proline-rich region
SITE: 641-644
MOTIF: proline residue (SEVERAL)
fibronectin type III domain or F3 module {720-828}
MOTIF: N-glycosylation site {N733}
fibronectin type III domain or F3 module {836-923}
fibronectin type III domain or F3 module {928-1031}
MOTIF: N-glycosylation site {N940}
fibronectin type III domain or F3 module {1033-1117}
proteolytic site {1197-1198}
transmembrane domain {1283-1303}
Tyrosine-protein phosphatase 1 {1393-1648}
MOTIF: binding site
SITE: 1557-1557
FOR-BINDING-OF: Substrate
Substrate binding {1589-1595}
cysteine residue {C1589}
binding site
SITE: 1633-1633
FOR-BINDING-OF: Substrate
Tyrosine-protein phosphatase 2 {1680-1939}
MOTIF: cysteine residue {C1880}
Database Correlations
OMIM 601576
UniProt Q13332
PFAM correlations
Entrez Gene 5802
Kegg hsa:5802
ENZYME 3.1.3.48
References
UniProt :accession Q13332