Search
receptor-type tyrosine-protein phosphatase R; R-PTP-R; Ch-1PTPase; NC-PTPCOM1; protein-tyrosine phosphatase PCPTP1 (PTPRR ECPTP PTPRQ)
Function:
- sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 & MAPK14 in the cytoplasm in an inactive form
- the MAPKs bind to a dephosphorylated kinase-interacting motif, phosphorylation of which by protein kinase A releases the MAPKs for activation & translocation into the nucleus (putative)
- interacts with MAPKs (putative)
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 7 subfamily
- contains 1 tyrosine-protein phosphatase domain
Compartment:
- isoform alpha:
- cell membrane; single-pass type 1 membrane protein
- isoform delta:
- cytoplasm, perinuclear region
- locates to the perinuclear areas within the cytoplasm
- isoform gamma
- cytoplasm, perinuclear region
- locates to the perinuclear areas within the cytoplasm
Alternative splicing: named isoforms=3; alpha, gamma, delta
Expression:
- expressed in brain, placenta, small intestine, stomach, uterus
- weakly expressed in the prostate
- isoform alpha has been observed only in the brain
- isoform gamma is expressed in brain, placenta & uterus
- isoform delta is expressed in brain, kidney, placenta, prostate, small intestine & uterus
General
receptor
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 657 aa
MW = 74 kD
COMPARTMENT: cytoplasm
cell nucleus
cellular membrane
STATE: active state
MOTIF: signal sequence {1-21}
N-glycosylation site {N129}
transmembrane domain {228-248}
Ser phosphorylation site {S339}
Tyr phosphorylation site {Y370}
Tyrosine-protein phosphatase {393-647}
MOTIF: binding site
SITE: 554-554
FOR-BINDING-OF: Substrate
Substrate binding {588-594}
cysteine residue {C588}
binding site
SITE: 632-632
FOR-BINDING-OF: Substrate
Database Correlations
OMIM 602853
UniProt Q15256
Pfam PF00102
Entrez Gene 5801
KEGG correlations
ENZYME 3.1.3.48
References
UniProt :accession Q15256