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receptor-type tyrosine-protein phosphatase O; R-PTP-O; glomerular epithelial protein 1; protein tyrosine phosphatase U2; PTP-U2; PTPase U2 (PTPRO, GLEPP1, PTPU2)
Function:
- possesses tyrosine phosphatase activity
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- belongs to the protein-tyrosine phosphatase family receptor class 3 subfamily
- contains 8 fibronectin F3 modules
- contains 1 tyrosine-protein phosphatase domain
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
Expression:
- glomerulus of kidney
- also detected in brain, lung & placenta
- induced by various differentiation-inducing agents
General
receptor
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1216 aa
MW = 138 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-29}
MOTIF: N-glycosylation site {N26}
fibronectin type III domain or F3 module {50-124}
MOTIF: N-glycosylation site {N75}
fibronectin type III domain or F3 module {142-211}
MOTIF: N-glycosylation site {N154}
N-glycosylation site {N189}
N-glycosylation site {N201}
N-glycosylation site {N227}
fibronectin type III domain or F3 module {246-306}
MOTIF: N-glycosylation site {N278}
N-glycosylation site {N287}
N-glycosylation site {N323}
N-glycosylation site {N324}
fibronectin type III domain or F3 module {327-399}
MOTIF: N-glycosylation site {N370}
fibronectin type III domain or F3 module {434-508}
MOTIF: N-glycosylation site {N461}
N-glycosylation site {N490}
fibronectin type III domain or F3 module {528-608}
fibronectin type III domain or F3 module {630-703}
MOTIF: N-glycosylation site {N700}
N-glycosylation site {N712}
fibronectin type III domain or F3 module {723-793}
MOTIF: N-glycosylation site {N733}
transmembrane domain {823-843}
Tyrosine-protein phosphatase {938-1195}
MOTIF: binding site
SITE: 1102-1102
FOR-BINDING-OF: Substrate
Substrate binding {1136-1142}
cysteine residue {C1136}
binding site
SITE: 1180-1180
FOR-BINDING-OF: Substrate
Database Correlations
OMIM 600579
UniProt Q16827
PFAM correlations
Entrez Gene 5800
Kegg hsa:5800
ENZYME 3.1.3.48
References
- UniProt :accession Q16827
- OMIM :accession 600579