Search
receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; phogrin (PTPRN2, KIAA0387)
Function:
- role in development of nervous system & pancreatic endocrine cells
- appears to undergo multiple proteolytic cleavage at consecutive basic residues
Kinetic parameters:
- pH dependence:
- Optimum pH is 4.5
protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Structure:
- the cytoplasmic domain appears to contain the autoantigenic epitopes
- belongs to the protein-tyrosine phosphatase family receptor class 8 subfamily
- contains 1 tyrosine-protein phosphatase domain
Compartment:
- membrane; single-pass type 1 membrane protein (probable)
Alternative splicing: named isoforms=3
Expression:
- highest levels in brain & pancreas
- lower levels in trachea, prostate, stomach & spinal cord
Pathology:
- autoantigen in insulin-dependent diabetes mellitus (IDDM)
General
receptor
tyrosine phosphatase, receptor type
Properties
SIZE: entity length = 1015 aa
MW = 111 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-21}
proteolytic site {427-428}
N-glycosylation site {N564}
transmembrane domain {616-636}
Ser phosphorylation site {S692}
Tyrosine-protein phosphatase {745-1005}
MOTIF: binding site
SITE: 913-913
FOR-BINDING-OF: Substrate
Substrate binding {945-951}
cysteine residue {C945}
Thr phosphorylation site {T977}
binding site
SITE: 990-990
FOR-BINDING-OF: Substrate
Database Correlations
OMIM 601698
UniProt Q92932
PFAM correlations
Entrez Gene 5799
Kegg hsa:5799
ENZYME 3.1.3.48
References
UniProt :accession Q92932