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protein turtle homolog A (immunoglobulin superfamily member 9A, IGSF9, IGSF9A, KIAA1355 ,NRT1)
Function:
- dendrite outgrowth & synapse maturation
- interacts with MAGI2 & SHANK1 (putative)
Structure:
- PDZ-binding motif mediates interactions with MAGI2 & SHANK1 (putative)
- belongs to the immunoglobulin superfamily, Turtle family
- contains 2 fibronectin F3 modules
- contains 5 Ig-like (immunoglobulin-like) domains
Compartment:
- cell membrane
- enriched at the excitatory synapses in mature neurons (putative)
- expressed in a wide variety of tissues at 8 & 14 weeks of gestation
General
glycoprotein
immunoglobulin superfamily protein
membrane protein
Properties
SIZE: entity length = 1179 aa
MW = 127 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {24-124}
MOTIF: cysteine residue {C41}
MODIFICATION: cysteine residue {C108}
cysteine residue {C108}
MODIFICATION: cysteine residue {C41}
immunoglobulin superfamily domain {136-216}
MOTIF: cysteine residue {C158}
MODIFICATION: cysteine residue {C206}
N-glycosylation site {N188}
cysteine residue {C206}
MODIFICATION: cysteine residue {C158}
immunoglobulin superfamily domain {226-318}
MOTIF: cysteine residue {C248}
MODIFICATION: cysteine residue {C301}
N-glycosylation site {N256}
cysteine residue {C301}
MODIFICATION: cysteine residue {C248}
immunoglobulin superfamily domain {322-410}
MOTIF: cysteine residue {C344}
MODIFICATION: cysteine residue {C395}
cysteine residue {C395}
MODIFICATION: cysteine residue {C344}
immunoglobulin superfamily domain {418-502}
MOTIF: cysteine residue {C440}
MODIFICATION: cysteine residue {C486}
cysteine residue {C486}
MODIFICATION: cysteine residue {C440}
fibronectin type III domain or F3 module {508-604}
MOTIF: N-glycosylation site {N513}
N-glycosylation site {N524}
fibronectin type III domain or F3 module {623-714}
transmembrane domain {735-755}
proline-rich region
SITE: 823-982
MOTIF: proline residue (SEVERAL)
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 1177-1179
FOR-BINDING-VIA: PDZ domain
Database Correlations
UniProt Q9P2J2
PFAM correlations
References
UniProt :accession Q9P2J2