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protein (total) in serum

Reference values: - Male & Female: 6.3 - 8.3 g/dL - serum albumin: 3.5-5.1 g/dL - serum globulin: 2.5-3.5 g/dL Clinical significance: Serum proteins function to transport drugs & metabolites, & they maintain the plasma osmotic pressure. The majority of serum proteins are synthesized in the liver with the exception of gamma globulins. One of the most important serum proteins produced in the liver is albumin. The total serum protein can be used for evaluation of the nutritional status. Increases: 1) causes of high total serum protein include a) dehydration b) Waldenstrom's macroglobulinemia c) multiple myeloma d) hypergammaglobulinemia e) granulomatous disease f) some tropical diseases. 2) total protein is occasionally increased in a) connective tissue diseases b) lupus erythematosus c) other instances of chronic infection or inflammation 3) pharmaceutical agents: a) in vivo effects -> ACTH, corticosteroids, anabolic steroids, b) chemical interferences -> bromsulphalein (BSP) dye, bilirubin, dextran, phenazopyridine Decreases: 1) causes of low total serum protein include a) pregnancy b) excessive intravenous fluid administration c) cirrhosis or other liver diseases, d) chronic alcoholism e) heart failure f) nephrotic syndrome g) glomerulonephritis h) neoplasia i) protein losing enteropathies j) malabsorption k) severe malnutrition 2) pharmaceutical agents: -> chemical interferences -> acetylsalicylic acid Principle: see protein in body fluid Specimen: see protein in body fluid Interferences: see protein in body fluid

Related

albumin in serum/plasma serum protein electrophoresis (SPE)

Specific

globulin in serum/plasma protein immunogenic in serum/plasma

General

protein in body fluid

References

  1. Kodak Ektachem 700 Analyzer Operator's Manual, Kodak Clinical Products, Rochester, New York.
  2. Kodak Ektachem Slide Package Inserts, Kodak Clinical Products Rochester, New York.
  3. Kodak Ektachem Training Manual, Kodak Clinical Products, Rochester, New York.
  4. Young, D. S., Pestaner, L. C., Gibberman, V: Effects of drugs on clinical chemistry tests. Clinical Chemistry (Special Issue) 21, April 1975.
  5. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 11.
  6. Protein, Total, Serum or Plasma Laboratory Test Directory ARUP: 20029
  7. Panel of 15 tests Laboratory Test Directory ARUP: 20408
  8. Panel of 7 tests Laboratory Test Directory ARUP: 20416
  9. Panel of 10 tests Laboratory Test Directory ARUP: 50615
  10. Panel of 6 tests Laboratory Test Directory ARUP: 50640
  11. Panel of 17 tests Laboratory Test Directory ARUP: 51223
  12. Panel of 16 tests Laboratory Test Directory ARUP: 51225
  13. Panel of 7 tests Laboratory Test Directory ARUP: 2002109
  14. Panel of 10 tests Laboratory Test Directory ARUP: 2002715

Component-of

albumin/protein total in serum alpha-1 globulin/protein.total in serum/plasma alpha-2 globulin/protein.total in serum/plasma alpha-2-macroglobulin/total protein in serum beta-1 globulin/total protein in serum beta-2 globulin/total protein in serum bone/joint panel calcium/protein in serum/plasma chemistry 14 panel (comprehensive metabolic panel, CMP, chem 12, SMA12, SMA20) enteral/parenteral nutrition management panel liver (function) tests (LFT, liver panel, hepatic function panel) parathyroid panel protein/creatinine in serum/plasma