Search
protein spire homolog 2 (spir-2, SPIRE2, KIAA1832, SPIR2)
Function:
- acts as a actin nucleation factor
- remains associated with the slow-growing pointed end of the new filament
- involved in vesicle transport processes providing a novel link between actin organization & intracellular transport (putative)
Structure:
- binds to actin monomers via the WH2 domain
- the spir-box targets binding to intracellular membrane structures (putative)
- belongs to the spire family
- contains 3 WH2 domains
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=4
General
cytoskeletal protein
Properties
SIZE: entity length = 714 aa
MW = 80 kD
COMPARTMENT: cytoplasm
MOTIF: WH2 1 {248-262}
WH2 2 {278-296}
WH2 3 {342-359}
Spir-box {534-554}
cysteine-rich region {572-599}
Database Correlations
UniProt Q8WWL2
Kegg hsa:8450
References
UniProt :accession Q8WWL2