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protein spire homolog 1 (spir-1, SPIRE1, KIAA1135, SPIR1)
Function:
- acts as a actin nucleation factor
- remains associated with the slow-growing pointed end of the new filament
- involved in vesicle transport processes providing a novel link between actin organization & intracellular transport
Structure:
- binds to actin monomers via the WH2 domain
- Spir-box targets binding to intracellular membrane structures
- belongs to the spire family
- contains 2 WH2 domains
Compartment:
- cytoplasm
- punctate spots in perinuclear region & cytoplasm, co-localised with Rab11
Alternative splicing: named isoforms=2
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 597 aa
MW = 69 kD
COMPARTMENT: cytoplasm
MOTIF: coiled coil {70-98}
WH2 1 {146-164}
WH2 2 {210-227}
Ser phosphorylation site {S305}
Ser phosphorylation site {S306}
Ser phosphorylation site {S308}
Spir-box {397-417}
Database Correlations
UniProt Q08AE8
References
UniProt :accession Q08AE8