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protein SETSIP; SET pseudogene protein 18; SET similar protein; similar to SET translocation protein (SETSIP, SETP18)
Function:
- role as a transcriptional activator involved in the early stage of somatic cell reprogramming
- promotes differentiation of protein-induced pluripotent stem cells into endothelial cells & the formation of vascular-like tubes (in vitro)
- role in induction of vascular endothelial (VE)-cadherin expression
- associates with VE-cadherin gene promoter
Compartment:
- cytoplasm. nucleus
- translocated from the cytoplasm to the nucleus in protein- induced pluripotent stem (PiPS) endothelial cells
Expression:
- expressed in endothelial cells (at protein level)
- up-regulated during protein-induced pluripotent stem cell - endothelial cell differentiation
- up-regulated by VEGFA & POU2F1 (at protein level)
Genetics:
- probable retrogene derived from SET transcript
Note:
- uncertain whether Met-1 or Met-11 is the initiator
General
nuclear protein
Properties
SIZE: entity length = 302 aa
MW = 35 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: coiled coil {45-88}
Database Correlations
UniProt P0DME0
Pfam PF00956
Entrez Gene 646817
References
UniProt :accession P0DME0