protein SDA1 homolog (SDA1 domain-containing protein 1, hSDA, nucleolar protein 130, SDAD1, NUC130)

Function: - required for 60S pre-ribosomal subunits export to the cytoplasm Structure: belongs to the SDA1 family Compartment: nucleus, nucleolus Alternative splicing: named isoforms=2 Expression: - expressed in testis, kidney, spleen, brain & fetal tissues > heart, lung, liver, small intestine, ovary, uterus, mammary gland & placenta - DAZL & PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation Polymorphism: - variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 80 kD entity length = 687 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {253-315} Ser phosphorylation site {S585}

Database Correlations

UniProt Q9NVU7 PFAM correlations

References

UniProt :accession Q9NVU7