protein ripply1 (RIPPLY1)

Function: - role in somitogenesis - essential for transcriptional repression of segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm - also required for the maintenance of rostrocaudal polarity insomites (putative) Structure: - ripply homology domain is required for transcriptional repression (putative) - WRPW motif is required for binding to TLE/GROUCHO proteins (putative) - belongs to the ripply family Compartment: nucleus (putative) Alternative splicing: named isoforms=2

Properties

SIZE: entity length = 151 aa MW = 16 kD COMPARTMENT: cell nucleus MOTIF: alanine-rich region {4-10} MOTIF: alanine residue (SEVERAL) WRPW {57-60} Ripply homology {96-131} glutamate-rich region {137-150} MOTIF: glutamate residue (SEVERAL)

References

UniProt :accession Q0D2K3