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protein RCC2 (telophase disk protein of 60 kD, RCC1-like protein TD-60, RCC2, KIAA1470, TD60)
Function:
1) completion of mitosis & cytokinesis
2) guanine nucleotide exchange factor for small GTPase RAC1
3) binds preferentially to the nucleotide-free form of RAC1
4) interacts with microtubules
Structure:
- contains 7 RCC1 repeats
Compartment:
- nucleus, nucleolus
- appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase
- redistributes to the midzone of the mitotic spindle during anaphase
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: MW = 56 kD
entity length = 522 aa
COMPARTMENT: cell nucleus
MOTIF: RCC1 repeat {103-165}
RCC1 repeat {168-219}
RCC1 repeat {221-271}
RCC1 repeat {273-347}
RCC1 repeat {348-401}
RCC1 repeat {403-447}
RCC1 repeat {448-501}
Database Correlations
UniProt Q9P258
Pfam PF00415
References
UniProt :accession Q9P258