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CD82 (metastasis suppressor Kangai 1, KAI1, C33 antigen, IA4, inducible membrane protein R2, tetraspanin-27, Tspan-27)
Function:
- roles in signal transduction & T cell activation.
- CD82 expression correlates with p53 expression.
- associates with CD4 or CD8 & gives costimulatory signals for T cell receptor pathway
- CD82 cross-linking promotes activation of human monocytic cell lines
Expression:
- activated/differentiated hematopoietic cells
- negative antibody staining in erythrocytes
Pathology:
- prostate cancer antimetastasis gene (protein) kang ai (KAI1)
- transfection of CD82 inhibited metastatic potential of prostate cancer cells in rat
- CD82 expression is correlated with metastatic potential in humans
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
tetraspanin (transmembrane-4-superprotein)
Properties
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
MOTIF: cysteine residue {exoplasmic loop [L2] } (5)
LOOP#: 2
glycosylation site
membrane region
cytoplasmic domain {C-TERMINAL}
MOTIF: cysteine residue {CYTOPLASMIC-TAIL}
Database Correlations
OMIM 600623
UniProt P27701
Entrez Gene 3732
References
- Protein Reviews on the Web
http://mpr.nci.nih.gov/prow/guide/1511855925_g.htm
- http://www.pathologyoutlines.com/cdmarkers.html
20 May 2003