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protein phosphatase methylesterase 1; PME-1 (PPME1, PME1, PP2593 PRO0750)
Function:
- demethylates proteins that have been reversibly carboxymethylated
- demethylates PPP2CB (in vitro) & PPP2CA
- binds protein phosphatase 2A (PPP2CA & PPP2CB)
- binding to PPP2CA displaces the Mn+2 & inactivates PPME1
- phosphorylated by SIK1 following increases in intracellular Na+, leading to dissociation from protein phosphatase 2A & subsequent dephosphorylation of Na+/K+-transporting ATPase ATP1A1 (putative)
Structure: belongs to the AB hydrolase superfamily
Alternative splicing: named isoforms=3
General
demethylase
Properties
SIZE: entity length = 386 aa
MW = 42 kD
MOTIF: Ser phosphorylation site {S15}
Ser phosphorylation site {S27}
Ser phosphorylation site {S42}
serine residue {S156}
aspartate residue {D181}
Ser phosphorylation site {S243}
glutamate-rich region {256-263}
MOTIF: glutamate residue (SEVERAL)
histidine residue {H349}
Database Correlations
OMIM 611117
UniProt Q9Y570
Entrez Gene 51400
Kegg hsa:51400
References
UniProt :accession Q9Y570