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Protein OS-9 (amplified in osteosarcoma 9, OS9)
Function:
- role in the ER-associated degradation of misfolded glycoproteins
Structure:
- belongs to the OS-9 family
- contains 1 PRKCSH domain
Alternative splicing: named isoforms=3
Expression:
- ubiquitously expressed
- isoform 2 major isoform detected in all cell types examined
Pathology:
- found in all tumor cell lines analyzed
- amplified in sarcomas
- highly expressed in osteosarcoma OSA-CL & rhabdomyosarcoma RH30 cell lines
General
glycoprotein
Properties
SIZE: MW = 76 kD
entity length = 667 aa
MOTIF: signal sequence {1-25}
PRKCSH {108-178}
MOTIF: N-glycosylation site {N177}
acidic region {414-429}
MOTIF: acidic residue (SEVERAL)
Database Correlations
UniProt Q13438
Pfam PF07915
References
UniProt :accession Q13438