protein NGX6; nasopharyngeal carcinoma-associated gene 6 protein; protein NAG-5 (C9orf127, NGX6, TMEM8B)

Function: - may function as a regulator of the EGFR pathway - probable tumor suppressor - may function in cell growth, proliferation & adhesion - isoform 2 (via its cytoplasmic part) interacts with EZR Structure: - isoform 2 is N-glycosylated - belongs to the NGX6 family - contains 1 EGF-like domain Compartment: - isoform 2: cell membrane - cytoplasm, nucleus (probable) - also detected in mitochondrion & endoplasmic reticulum Alternative splicing: named isoforms=3 Pathology: - isoform 2 is down-regulated in nasopharyngeal carcinoma cells

General

glycoprotein membrane protein

Properties

SIZE: entity length = 472 aa MW = 52 kD COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: exoplasmic domain {1-233} MOTIF: N-glycosylation site {N92} N-glycosylation site {N100} EGF domain {182-221} cysteine residue {C186} MODIFICATION: cysteine residue {C196} cysteine residue {C190} MODIFICATION: cysteine residue {C209} cysteine residue {C196} MODIFICATION: cysteine residue {C186} cysteine residue {C209} MODIFICATION: cysteine residue {C190} cysteine residue {C211} MODIFICATION: cysteine residue {C220} cysteine residue {C220} MODIFICATION: cysteine residue {C211} transmembrane domain {234-254} cytoplasmic loop {255-257} transmembrane domain {258-277} exoplasmic loop {278-292} transmembrane domain {293-313} cytoplasmic loop {314-315} transmembrane domain {316-336} exoplasmic loop {337-342} transmembrane domain {343-363} cytoplasmic loop {364-379} transmembrane domain {380-400} exoplasmic loop {401-405} transmembrane domain {406-426} cytoplasmic domain {427-472}

Database Correlations

UniProt A6NDV4 Kegg hsa:5175

References

UniProt :accession A6NDV4