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serine/threonine protein kinase N3; protein kinase PKN-beta; protein-kinase C-related kinase 3 (PKN3, PKNBETA)
Function:
- serine/threonine protein kinase
- two specific sites, Thr-718 (activation loop of kinase domain) & Thr-860 (turn motif), need to be phosphorylated for full activation (putative)
- autophosphorylated
Structure:
- the C1 domain does not bind the diacylglycerol (DAG)
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
- contains 1 AGC-kinase C-terminal domain
- contains 1 protein kinase domain
- contains 3 REM (Hr1) repeats
Compartment:
- nucleus, cytoplasm, perinuclear region
- nuclear & perinuclear Golgi region
Expression:
- expressed in prostate tumors & various cancer cell lines
- not expressed in adult tissues
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 889 aa
MW = 99 kD
COMPARTMENT: cytoplasm
cell nucleus
golgi
MOTIF: REM {18-90}
REM {105-181}
REM {182-255}
Ser phosphorylation site {S307}
proline-rich region
SITE: 463-554
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T508}
Ser phosphorylation site {S544}
Ser phosphorylation site {S548}
Thr phosphorylation site {T550}
kinase domain
SITE: 559-818
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 565-573
ATP-binding site
NAME: ATP-binding site
SITE: 588-588
aspartate residue {D684}
Thr phosphorylation site {T716}
Thr phosphorylation site {T718}
Thr phosphorylation site {T722}
AGC-kinase C-terminal {819-889}
MOTIF: Thr phosphorylation site {T860}
STATE: active state
Database Correlations
OMIM 610714
UniProt Q6P5Z2
PFAM correlations
Entrez Gene 29941
Kegg hsa:29941
ENZYME 2.7.11.13
References
UniProt :accession Q6P5Z2