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protein KIAA1324 (estrogen-induced gene 121 protein, KIAA1324, EIG121, UNQ2426/PRO4985)
Function:
- marker of hyperestrogenic state and estrogen-related type 1 endometrial carcinoma
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- expressed in normal endometrium but
- induced by estrogen replacement therapy
Pathology:
- marker of estrogen-related type 1 endometrial carcinoma
- overexpressed in endometroid tumors
General
glycoprotein
membrane protein
Properties
SIZE: MW = 111 kD
entity length = 1013 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-41}
N-glycosylation site {N153}
cysteine residue {C278}
MODIFICATION: cysteine residue {C295}
cysteine residue {C295}
MODIFICATION: cysteine residue {C278}
cysteine residue {C308}
MODIFICATION: cysteine residue {C330}
cysteine residue {C311}
MODIFICATION: cysteine residue {C342}
cysteine residue {C330}
MODIFICATION: cysteine residue {C308}
cysteine residue {C342}
MODIFICATION: cysteine residue {C311}
N-glycosylation site {N404}
N-glycosylation site {N672}
transmembrane domain {911-931}
Database Correlations
UniProt Q6UXG2
References
UniProt :accession Q6UXG2