E3 SUMO-protein ligase PIAS3; protein inhibitor of activated STAT protein 3 (PIAS3)

Function: - E3-type small ubiquitin-like modifier (SUMO) ligase - stabilizes interaction between UBE2I & substrate - SUMO-tethering factor - role in transcriptional coregulation in cellular pathways a) STAT pathway b) steroid hormone signaling pathway - effects of transcriptional coregulation, transactivation or silencing may depend upon context - sumoylated (putative) - binds SUMO1 & UBE2I - interacts with AR, BCL11A, GFI1, HMGA2, IRF1, MITF, NCOA2, in addition to STAT3, after treatment with IL6, CNTF or OSM interacts with STAT5 after PRL stimulation - interacts with PLAG1 - interacts with ZFHX3 Structure: - the LXXLL motif is a transcriptional coregulator signature - belongs to the PIAS family - contains 1 PINIT domain - contains 1 SAP domain - contains 1 SP-RING-type Zn⁺² finger Compartment: nuclear speckle (putative) Expression: - widely expressed - induced by dihydrotestosterone in prostate cancer cells

General

nuclear protein ring finger protein

Properties

SIZE: entity length = 628 aa MW = 68 kD COMPARTMENT: cell nucleus MOTIF: SAP {11-45} MOTIF: LXXLL {19-23} proline-rich region SITE: 81-133 MOTIF: proline residue (SEVERAL) PINIT {115-280} RING-finger {303-380} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif binding site SITE: 450-460 FOR-BINDING-OF: small ubiquitin-related modifier 1

Database Correlations

OMIM 605987 UniProt Q9Y6X2 Pfam PF02891 Entrez Gene 10401 Kegg hsa:10401

References

UniProt :accession Q9Y6X2