protein inhibitor of activated STAT (PIAS)

Originally identified as inhibitors of the STAT family of signal transducers & transcription factors. It appears now the PIAS proteins function as E3-like ligases in protein sumoylation.

Specific

E3 SUMO-protein ligase PIAS2; androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; Miz1; PIAS-NY protein; protein inhibitor of activated STAT x; protein inhibitor of activated STAT2 (PIAS2, PIASX) E3 SUMO-protein ligase PIAS3; protein inhibitor of activated STAT protein 3 (PIAS3) E3 SUMO-protein ligase PIAS4; PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein gamma; PIAS-gamma (PIAS4, PIASG) protein inhibitor of activated STAT1 (PIAS1, DEAH box binding protein 1, DDXBP1)

References

- Scmidt D & Muller S PIAS/SUMO: new partners in transcriptional regulation. Cell Mol Life Sci. 2003 Dec;60(12):2561-74. PMID: 14685683