protein INCA1 (inhibitor of CDK interacting with cyclin A1) (INCA1)

Function: - interacts with CCNA1 - identified in a complex with CCNA1 & CDK2 - phosphorylated when part of a complex with CCNA1 & CDK2 strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221 - less intensively phosphorylated by CDK2 on its first 75 amino acid residues Structure: belongs to the INCA family Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - detected in testis, & at lower levels in ovary Pathology: - detected at very low levels in testis tumors

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 236 aa MW = 27 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S23} nuclear translocation signal {90-95} Thr phosphorylation site {T182} Ser phosphorylation site {S191} Ser phosphorylation site {S194}

Database Correlations

UniProt Q0VD86 Kegg hsa:3883

References

UniProt :accession Q0VD86