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protein IkappaBNS; T-cell activation NFKB-like protein; TA-NFKBH (IKBNS, NFKBID)
Function:
- may regulate the expression of IL-2, IL-6, & other cytokines through regulation on NF-kappa-B activity
- functions in regulation of inflammatory responses
- may also regulate TCR- induced negative selection of thymocytes
- interacts with NFKB1, RELA & RELB; in the nucleus
Structure: contains 6 ANK repeats
Compartment: nucleus (putative)
Alternative splicing: named isoforms=3
General
ankyrin repeat domain protein (ANKRD)
nuclear protein
Properties
SIZE: entity length = 313 aa
MW = 33 kD
COMPARTMENT: cell nucleus
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 48-83
ankyrin repeat
NAME: ankyrin repeat
SITE: 84-113
ankyrin repeat
NAME: ankyrin repeat
SITE: 117-146
ankyrin repeat
NAME: ankyrin repeat
SITE: 152-201
ankyrin repeat
NAME: ankyrin repeat
SITE: 206-236
ankyrin repeat
NAME: ankyrin repeat
SITE: 243-276
Database Correlations
UniProt Q8NI38
Pfam PF00023
Kegg hsa:8480
References
UniProt :accession Q8NI38