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protein HEXIM2 (hexamethylene bis-acetamide-inducible protein 2, HEXIM2)
Function:
- transcriptional regulator
- functions as a general RNA polymerase 2 transcription inhibitor
- in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase 2 phosphorylation & subsequent transcriptional elongation
- homooligomer & heterooligomer with HEXIM1; probably dimeric
- component of the 7SK snRNP complex
Structure:
- coiled-coil domain mediates oligomerization
- belongs to the HEXIM family
Compartment: nucleus
Expression:
- ubiquitously expressed
- higher expression in testis
- HEXIM1 & HEXIM2 are differentially expressed
- up-regulated by HMBA (hexamethylene bisacetamide) (at protein level)
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 286 aa
MW = 32 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S51}
Ser phosphorylation site {S53}
P-TEFb interaction {140-143}
coiled coil {207-277}
CCNT1, HEXIM1 & HEXIM2 interaction {226-286}
Database Correlations
UniProt Q96MH2
References
UniProt :accession Q96MH2
Component-of
7SK SNRNP complex