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protein FEV; Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1 (FEV, PET1)
Function:
- transcriptional regulator
- may act as transcriptional repressor
- role in differentiation & maintenance of the central serotonergic neurons
- may play a role in cell growth
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
Compartment: nucleus
Expression:
- expressed in brain
- exclusively expressed in the major serotonergic neurons of the dorsal & median raphe nuclei located in the midbrain & pons
- also detected in prostate & small intestine
Pathology:
- genetic variation in FEV may be associated with susceptibility to sudden infant death syndrome
- chromosomal translocation t(2;21;22)(q23;q22;q12) involving FEV with EWSR1 is found in Ewing tumors; translocation forms a EWSR1-FEV fusion protein with potential oncogenic activity
General
nuclear protein
Properties
SIZE: entity length = 238 aa
MW = 25 kD
COMPARTMENT: cell nucleus
MOTIF: Breakpoint {18-19}
ETS domain
NAME: ETS domain
SITE: 47-127
silencer element
SITE: 129-238
MOTIF: alanine-rich region {132-210}
MOTIF: alanine residue (SEVERAL)
Database Correlations
UniProt Q99581
Pfam PF00178
Kegg hsa:5473
References
- UniProt :accession Q99581