protein fem-1 homolog C (FEM1-gamma, FEM1c, FEM1C, KIAA1785)

Function: - probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit component of some E3 ubiquitin-protein ligase complex protein degradation; protein ubiquitination Structure: - belongs to the fem-1 family - contains 9 ANK repeats - contains 2 TPR repeats Compartment: cytoplasm (putative) Expression: - widely expressed - highly expressed in kidney, cardiac tissue, skeletal muscle & testis - expressed at lower levels in other tissues, including cartilage Note: Was initially thought to be the ortholog of mouse FEM1A

Properties

SIZE: entity length = 617 aa MW = 69 kD COMPARTMENT: cytoplasm MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 2-31 ankyrin repeat NAME: ankyrin repeat SITE: 40-70 ankyrin repeat NAME: ankyrin repeat SITE: 82-111 ankyrin repeat NAME: ankyrin repeat SITE: 115-144 ankyrin repeat NAME: ankyrin repeat SITE: 148-177 ankyrin repeat NAME: ankyrin repeat SITE: 181-210 ankyrin repeat NAME: ankyrin repeat SITE: 213-242 tetratricopeptide repeat {245-279} tetratricopeptide repeat {338-371} ankyrin repeat NAME: ankyrin repeat SITE: 481-523 ankyrin repeat NAME: ankyrin repeat SITE: 527-556

Database Correlations

OMIM 608767 UniProt Q96JP0 Pfam PF00023 Kegg hsa:5692