protein fem-1 homolog B (FEM1-beta, FEM1b, Fem-1-like death receptor-binding protein alpha, F1A-alpha, FEM1B, F1AA, KIAA0396)

Function: - component of an ECS E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit - involved in apoptosis by acting as a death receptor- associated protein that mediates apoptosis - also involved in glucose homeostasis in pancreatic islet - protein degradation; protein ubiquitination - interacts with PPM1F & PHTF1 - interacts with the death domain of FAS/TNFRSF6 & TNFRSF1A Structure: - homooligomer - belongs to the fem-1 family - contains 8 ANK repeats - contains 1 TPR repeat Compartment: cytoplasm (putative) Expression: - widely expressed - expressed in testis > other tissues

General

ankyrin repeat domain protein (ANKRD) receptor

Properties

SIZE: entity length = 627 aa MW = 70 kD COMPARTMENT: cytoplasm MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 45-74 ankyrin repeat NAME: ankyrin repeat SITE: 87-116 ankyrin repeat NAME: ankyrin repeat SITE: 120-149 ankyrin repeat NAME: ankyrin repeat SITE: 153-182 ankyrin repeat NAME: ankyrin repeat SITE: 186-215 ankyrin repeat NAME: ankyrin repeat SITE: 218-248 peptide motif {342-343} tetratricopeptide repeat {344-377} ankyrin repeat NAME: ankyrin repeat SITE: 483-527 ankyrin repeat NAME: ankyrin repeat SITE: 531-568

Database Correlations

UniProt Q9UK73 Pfam PF00023 Kegg hsa:1011

References

UniProt :accession Q9UK73