protein disulfide reductase (GSH); GSH insulin transhydrogenase

General

multisubunit protein oxidoreductase

Properties

MOTIF: active site SUBUNITS: protein subunit protein disulfide isomerase MOTIF: signal sequence {1-17} thioredoxin domain SITE: 25-134 MOTIF: cysteine residue {C53} MODIFICATION: cysteine residue {C56} cysteine residue {C53} Contributes to redox potential value {54-54} Contributes to redox potential value {55-55} cysteine residue {C56} cysteine residue {C56} MODIFICATION: cysteine residue {C53} Lowers pKa of C-terminal Cys of first active site {120-120} thioredoxin domain SITE: 368-475 MOTIF: cysteine residue {C397} MODIFICATION: cysteine residue {C400} cysteine residue {C397} Contributes to redox potential value {398-398} Contributes to redox potential value {399-399} cysteine residue {C400} cysteine residue {C400} MODIFICATION: cysteine residue {C397} Lowers pKa of C-terminal Cys of second active site {461-461} Prevents secretion from ER {505-508}

Components

protein disulfide isomerase (cellular thyroid hormone binding protein, prolyl 4-hydroxylase subunit beta, P4HB, ERBA2L, PDI, PDIA1, PO4DB) protein subunit