protein disulfide-isomerase TXNDC10 (thioredoxin domain-containing protein 10, thioredoxin-related transmembrane protein 3, TXNDC10, KIAA1830, TMX3)

Function: - probable disulfide isomerase - role in folding of proteins containing disulfide bonds - may act as a dithiol oxidase - catalyzes rearrangement of -S-S- bonds in proteins Redox potential: E(0) is -157 mV Structure: - belongs to the protein disulfide isomerase family - contains 1 thioredoxin domain - di-lysine motif confers endoplasmic reticulum localization for type 1 membrane proteins - N-glycosylated Compartment: endoplasmic reticulum membrane Alternative splicing: named isoforms=2 Expression: - widely expressed - expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye, muscle - not up-regulated by unfolded protein response

General

glycoprotein membrane protein protein disulfide isomerase (cellular thyroid hormone binding protein, prolyl 4-hydroxylase subunit beta, P4HB, ERBA2L, PDI, PDIA1, PO4DB)

Properties

SIZE: MW = 52 kD entity length = 454 aa COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-24} thioredoxin domain SITE: 25-128 MOTIF: cysteine residue {C53} MODIFICATION: cysteine residue {C56} cysteine residue {C56} MODIFICATION: cysteine residue {C53} N-glycosylation site {N258} N-glycosylation site {N313} transmembrane domain {376-396} Lys-Lys {451-454}

Database Correlations

UniProt Q96JJ7 Pfam PF00085 ENZYME 5.3.4.1

References

UniProt :accession Q96JJ7