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protein dispatched homolog 1 (DISP1 DISPA)
Function:
- functions in hedgehog (Hh) signaling
- regulates the release & extracellular accumulation of cholesterol-modified hedgehog proteins, thus required for effective production of the Hh signal (putative)
Structure:
- belongs to the dispatched family
- contains 1 SSD (sterol-sensing) domain
Compartment: membrane (putative)
General
glycoprotein
membrane protein
Properties
SIZE: entity length = 1524 aa
MW = 171 kD
COMPARTMENT: cellular membrane
MOTIF: N-glycosylation site {N59}
transmembrane domain {190-210}
sterol-sensing domain {486-658}
MOTIF: binding site
FOR-BINDING-OF: sterol
transmembrane domain {500-520}
transmembrane domain {525-545}
transmembrane domain {549-569}
N-glycosylation site {N582}
transmembrane domain {604-624}
transmembrane domain {638-658}
transmembrane domain {719-739}
transmembrane domain {988-1008}
transmembrane domain {1010-1030}
transmembrane domain {1040-1060}
transmembrane domain {1079-1099}
transmembrane domain {1107-1127}
Database Correlations
OMIM 607502
UniProt Q96F81
References
UniProt :accession Q96F81