protein DERPC (Decreased expression in renal & prostate cancer protein, DERPC)

Function: - potential tumor suppressor - inhibits prostate tumor cell growth, when overexpressed Compartment: nucleus Expression: - ubiquitously expressed - expressed in kidney, skeletal muscle, testis, heart > prostate Pathology: - expression is significantly diminished in renal cancer & prostate cancer - no differential expression in breast cancer cells, between lobular carcinoma & normal lobules - found in a common chromosomal region of deletion in breast cancer Genetics: - gene encoding this protein shares overlapping exons with CTF8 (UniProt Q8WV66 deleted from database Aug 2010) Notes: UniProt :accession Q8NDH8 deleted from database May 2010

Properties

SIZE: entity length = 524 aa MW = 51 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 4-524 MOTIF: proline residue (SEVERAL) glycine-rich region {101-328}