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protein C in plasma (protein C assay)

Specimen: 1) plasma (citrate) 2) stable at room temperature for 8 hours 3) stable at -20 degrees C for 1 month Reference values: 1) 70-140% of normal reference activity 2) 2.82-5.65 ug/mL Methods: 1) functional* clotting assay based on anticoagulant activity 2) rocket immunoelectrophoresis 3) enzyme-linked immunosorbant assays (ELISA) * NOT useful if patient is anticoagulated Increases: -> pharmaceutical agents: a) chemical interferences -> heparin, warfarin b) in vivo effects -> oral contraceptives, stanozolol Decreases: 1) pharmaceutical agents -> chemical interferences - high factor VIII activity 2) clinical disorders: hypercoagulability a) congenital deficiency - type 1: low functional & antigenic levels - type 2: low functional & normal antigenic levels b) acquired deficiency - liver disease - acute thrombosis [1] - warfarin therapy - protein-losing enteropathy [1]

Related

activated protein C (APC) resistance assay protein C antigen in plasma protein C deficiency protein C; vitamin K-dependent protein C; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; contains: vitamin K-dependent protein C light chain; vitamin K-dependent protein C heavy chain; activation peptide (PROC)

General

clinical hematology test

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 17, 18. American College of Physicians, Philadelphia 1998, 2015, 2018
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
  3. Protein C Functional Laboratory Test Directory ARUP: 30041
  4. Protein C Functional Laboratory Test Directory ARUP: 30113
  5. Panel of 4 tests Laboratory Test Directory ARUP: 30177
  6. Mini Panel of 2 tests: Protein C Functional . Protein S Functional Laboratory Test Directory ARUP: 30182
  7. Protein C Functional Laboratory Test Directory ARUP: 2003386