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protein CREG1 (cellular repressor of E1A-stimulated genes 1, CREG1, CREG, UNQ727/PRO1409)
Function:
- may contribute to the transcriptional control of cell growth & differentiation
- antagonizes transcriptional activation & cellular transformation by the adenovirus E1A protein
- transcriptional control activity of cell growth requires interaction with IGF2R
- interacts with IGF2R; interaction dependent on glycosylation
- N-glycosylated
Structure:
- homodimer
- belongs to the CREG family
Compartment: secreted
General
glycoprotein
secreted protein
Properties
SIZE: MW = 24 kD
entity length = 220 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-31}
N-glycosylation site {N160}
N-glycosylation site {N193}
N-glycosylation site {N216}
Database Correlations
UniProt O75629
References
UniProt :accession O75629