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protein conjugation
Covalent modification of a protein with ubiquitin, or a ubiquitin-like protein. Ubiquitin & ubiquitin-like proteins modify an epsilon amino group of lysine in the target protein via its C-terminal carboxyl-group. They are expressed as inactive precursors with extensions at their C-terminus preventing direct conjugation. The precursors are processed by specific proteases.
Specific
ISGylation
neddylation
protein sumoylation
ubiquitination
General
chemical conjugation
References
- Hemelaar J, Borodovsky A, Kessler BM, Reverter D et al
Specific and covalent targeting of conjugating and
deconjugating enzymes of ubiquitin-like proteins.
Mol Cell Biol. 2004 Jan;24(1):84-95.
PMID: 14673145