protein broad-minded; TBC1 domain family member 32 (TBC1D32, BROMI, C6orf170, C6orf171)

Function: - required for high-level Shh responses in the developing neural tube - interacts with CDK20, which promotes CDK20 stability & function - together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane & axoneme, allowing GLI2 to be properly activated in response to SHH signaling Structure: - contains 1 Rab-GAP TBC domain - the Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg & Gln in the catalytic finger motifs Compartment: cytoplasm, cell projection, cilium (putative) Alternative splicing: named isoforms=3

General

glycoprotein membrane protein

Properties

SIZE: entity length = 1257 aa MW = 145 kD COMPARTMENT: cytoplasm MOTIF: glycosylation site membrane region rab-GAP domain NAME: rab-GAP domain SITE: 1119-1242

Database Correlations

UniProt Q96NH3 Entrez Gene 221322 Kegg hsa:221322

References

UniProt :accession Q96NH3