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protein bicaudal D homolog 2 (Bic-D 2, BICD2, KIAA0699)
Function:
- may play a role in the dynein-dynactin interactions on the surface of membranous organelles
- regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (putative)
- interacts with DCTN2 & RAB6A (putative)
- interacts with NEK9
- phosphorylated by NEK9 in vitro
Structure:
- belongs to the BicD family
- 4th coiled coil region is involved in Golgi targeting & in the interaction with DCTN2 (putative)
Compartment:
- Golgi, cytoplasm, cytoskeleton
- in interphase cells mainly localizes to the Golgi, colocalizes with dynactin at microtubule plus ends
- its localization is dependent on microtubule morphology
Alternative splicing: named isoforms=2 (due to intron retention)
Expression: ubiquitous
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 94 kD
entity length = 824 aa
COMPARTMENT: cytoplasm
golgi
MOTIF: coiled coil {20-269}
coiled coil {338-537}
MOTIF: Tyr phosphorylation site {Y424}
Ser phosphorylation site {S582}
RAB6A interaction {663-803}
coiled coil {666-808}
MOTIF: Thr phosphorylation site {T691}
Database Correlations
UniProt Q8TD16
References
UniProt :accession Q8TD16