protein atonal homolog 8 (Helix-loop-helix protein hATH-6, ATOH8, HATH6)

Function: - putative transcription factor - may be implicated in specification & differentiation of neuronal cell lineages in the brain - may participate in kidney development & may be involved in podocyte differentiation (putative) - efficient DNA binding requires dimerization with another bHLH protein (putative) Structure: contains 1 basic helix-loop-helix (bHLH) domain Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: - expressed in lung, liver, kidney, heart & pancreas - expressed in endothelium of umbilical vessels

Properties

SIZE: entity length = 321 aa MW = 35 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 69-187 MOTIF: proline residue (SEVERAL) DNA-binding motif SITE: 228-242 helix-loop-helix NAME: helix-loop-helix SITE: 243-283 FOR-BINDING-VIA: helix-loop-helix

Database Correlations

UniProt Q96SQ7 Pfam PF00010 Kegg hsa:8491

References

UniProt :accession Q96SQ7