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protein AF-17 (mixed lineage leukemia translocated to 6, MLLT6, ALL1 fused gene from chromosome 17 protein, AF17)
Structure:
- contains 2 PHD-type zinc fingers
Compartment: nucleus
Pathology:
- a chromosomal translocation t(11;17)(q23;q21) involving MLLT6 with MLL/HRX is associated with acute leukemias
- the result is a rogue activator protein
Related
mixed lineage leukemia translocated to 6 (MLLT6, ALL1 fused gene from chromosome 17, AF17)
General
nuclear protein
zinc finger protein
Properties
SIZE: MW = 112 kD
entity length = 1093 aa
COMPARTMENT: cell nucleus
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 5-57
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 51-68
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 117-180
EFFECTOR-BOUND: Zn+2
serine-rich region {190-211}
MOTIF: serine residue (SEVERAL)
serine-rich region {275-282}
MOTIF: serine residue (SEVERAL)
serine-rich region {326-338}
MOTIF: serine residue (SEVERAL)
MLL FUSION POINT {551-551}
leucine zipper
SITE: 729-764
FOR-BINDING-VIA: leucine zipper
serine-rich region {822-829}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 834-862
MOTIF: proline residue (SEVERAL)
glutamine-rich region {935-984}
MOTIF: glutamine residue (SEVERAL)
alanine-rich region {1040-1051}
MOTIF: alanine residue (SEVERAL)
glycine-rich region {1069-1080}
Database Correlations
OMIM 600328
UniProt P55198
Pfam PF00628
References
- UniProt :accession P55198
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/AF17.html