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protein AF-10 (myeloid/lymphoid or mixed lineage leukemia translocated to 10, MLLT10, ALL1 fused gene from chromosome 10 protein, AF10)
Structure:
- contains 2 PHD-type zinc fingers
Compartment: nucleus
Expression: expressed abundantly in testis
Pathology:
1) chromosomal translocation t(10;11)(p12;q23) involving MLLT10 with MLL/HRX is associated with acute leukemias
- result is a rogue activator protein
2) chromosomal translocation t(10;11)(p13;q14) involving MLLT10 with PICALM is associated with diffuse histiocytic lymphomas
Related
mllt10 gene
General
nuclear protein
zinc finger protein
Properties
SIZE: MW = 109 kD
entity length = 1027 aa
COMPARTMENT: cell nucleus
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 22-74
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 68-85
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 134-197
EFFECTOR-BOUND: Zn+2
lysine-rich region {229-240}
MOTIF: lysine residue (SEVERAL)
MLL FUSION POINT {266-266}
MLL FUSION POINT {643-643}
MLL FUSION POINT {680-680}
leucine zipper
SITE: 766-794
FOR-BINDING-VIA: leucine zipper
serine-rich region {856-861}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 602409
UniProt P55197
Pfam PF00628
References
- UniProt :accession P55197
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/AF10.html