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protein AATF; apoptosis-antagonizing transcription factor; Rb-binding protein che-1 (AATF, CHE1, DED, HSPC277)
Function:
1) general inhibitor of the histone deacetylase HDAC1
2) binding to the pocket region of RB1
a) displaces HDAC1 from RB1/E2F complexes (putative)
b) activation of E2F target genes
c) cell cycle progression
3) binding of SP1
a) displaces HDAC1 from from SP1 bound to promotor
b) displacement of SP1 from the CDKN1A promoter leads to increased expression of CDK inhibitor & blocks cell cycle progression
4) antagonizes PAWR mediated induction of aberrant amyloid A4 peptide production in Alzheimer disease (putative)
5) binds PAWR, POLR2J, RB1, RBL1, RBL2, SP1, MAPT
6) hyperphosphorylated during the G1/S phase transition
Structure: belongs to the AATF family
Compartment: nucleus, nucleolus
Expression:
- ubiquitously expressed
- expressed at high levels in brain, heart, kidney, placenta, thymus
General
nuclear protein
phosphoprotein
Properties
SIZE: MW = 63 kD
entity length = 560 aa
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {96-195}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S203}
binding site
SITE: 273-315
FOR-BINDING-OF: RNA polymerase-2 p13.3
binding site
SITE: 316-372
FOR-BINDING-OF: retinoblastoma-associated protein
MOTIF: Ser phosphorylation site {S316}
Ser phosphorylation site {S320}
Ser phosphorylation site {S321}
binding site
SITE: 373-472
FOR-BINDING-OF: SP1
RB1
Database Correlations
OMIM 608463
UniProt Q9NY61
PFAM correlations
Entrez Gene 26574
Kegg hsa:26574
References
- UniProt :accession Q9NY61
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/AATFID534ch17q11.html