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guanine nucleotide-binding protein subunit beta-2-like 1; guanine nucleotide-binding protein subunit beta-like protein 12.3; receptor of activated protein kinase C 1; RACK1; receptor for activated C kinase; cell proliferation-inducing gene 21 protein; Human lung cancer oncogene 7 protein; HLC-7 (GNB2L1)
Function:
- seems to bind protein kinase C acting as an intracellular receptor to anchor activated PKC to the cytoskeleton
- may be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1
- together with KRT1 & ITGB1, serves as a platform for SRC activation or inactivation
- may play a role in the developing brain & neuronal differentiation
- binds SLC9A3R1
- forms a ternary complex with TRIM63 & PRKCE
- interacts with HABP4 & KRT1
Structure:
- the WD repeats domain 5 mediates interaction with TRIM63
- belongs to the WD repeat G protein beta family
- contains 7 WD repeats
Compartment:
- cell membrane
- located on plasma membrane of neuroblastoma NMB7 cells
General
phosphoprotein
receptor
WD repeat protein family
Properties
SIZE: entity length = 317 aa
MW = 35 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
WD repeat {13-44}
WD repeat {61-91}
WD repeat {103-133}
WD repeat {146-178}
WD repeat {190-220}
Tyr phosphorylation site {Y228}
WD repeat {231-260}
WD repeat {281-311}
Database Correlations
OMIM 176981
UniProt P63244
Pfam PF00400
Entrez Gene 10399
Kegg hsa:10399
References
- UniProt :accession P63244
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GNB2L1ID43285ch5q35.html
- Prosite :accession PS00678