Search
proteinase-activated receptor 4; PAR-4; thrombin receptor-like 3; coagulation factor II receptor-like 3 (F2RL3, PAR4)
Function:
- receptor for activated thrombin or trypsin
- coupled to G proteins that stimulate phosphoinositide hydrolysis
- may play a role in platelets activation
- a proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- widely expressed
- highest levels in lung, pancreas, thyroid, testis & small intestine
- also detected in platelets
- not expressed in brain, kidney, spinal cord & peripheral blood leukocytes
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 385 aa
MW = 41 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-82}
MOTIF: signal sequence {1-17}
peptide motif {47-48}
N-glycosylation site {N56}
transmembrane domain {83-103}
cytoplasmic loop {104-108}
transmembrane domain {109-129}
exoplasmic loop {130-151}
MOTIF: cysteine residue {C149}
MODIFICATION: cysteine residue {C228}
transmembrane domain {152-172}
cytoplasmic loop {173-192}
transmembrane domain {193-213}
exoplasmic loop {214-247}
MOTIF: cysteine residue {C228}
MODIFICATION: cysteine residue {C149}
transmembrane domain {248-268}
cytoplasmic loop {269-283}
transmembrane domain {284-304}
exoplasmic loop {305-319}
transmembrane domain {320-343}
cytoplasmic domain {344-385}
Database Correlations
OMIM 602779
UniProt Q96RI0
Pfam PF00001
Kegg hsa:9002
References
- UniProt :accession Q96RI0
- SeattleSNPs
http://pga.gs.washington.edu/data/f2rl3/