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proteinase-activated receptor 2; PAR-2; thrombin receptor-like 1; coagulation factor II receptor-like 1; G-protein coupled receptor 11 (F2RL1, GPR11, PAR2)
Function:
- receptor for trypsin & trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis
- may have a role in the regulation of vascular tone
- proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- widely expressed
- highly expressed in pancreas, liver, kidney, small intestine, & colon
- moderate expression is detected in many organs
- not expressed in brain or skeletal muscle
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 397 aa
MW = 44 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-75}
MOTIF: signal sequence {1-25}
N-glycosylation site {N30}
peptide motif {36-37}
transmembrane domain {76-101}
cytoplasmic loop {102-110}
transmembrane domain {111-130}
exoplasmic loop {131-149}
MOTIF: cysteine residue {C148}
MODIFICATION: cysteine residue {C226}
transmembrane domain {150-171}
cytoplasmic loop {172-190}
transmembrane domain {191-211}
exoplasmic loop {212-241}
MOTIF: N-glycosylation site {N222}
cysteine residue {C226}
MODIFICATION: cysteine residue {C148}
transmembrane domain {242-260}
cytoplasmic loop {261-285}
transmembrane domain {286-308}
exoplasmic loop {309-323}
transmembrane domain {324-347}
cytoplasmic domain {348-397}
MOTIF: serine-rich region {383-390}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 600933
UniProt P55085
Pfam PF00001
Kegg hsa:2150
References
- UniProt :accession P55085
- Wikipedia; protease-activated receptor entry
http://en.wikipedia.org/wiki/protease-activated_receptor
- SeattleSNPs
http://pga.gs.washington.edu/data/f2rl1/