Proteasome assembly chaperone 2 (PAC-2, tumor necrosis factor superfamily member 5-induced protein 1, hepatocellular carcinoma-susceptibility protein 3, PSMG2, HCCA3, PAC2, TNFSF5IP1)

Function: - chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1 - the PSMG1-PSMG2 heterodimer binds to the PSMA5 & PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring & prevents alpha ring dimerization - forms a heterodimer with PSMG1 - the PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 & PSMA7 proteasome alpha subunits - degraded by the proteasome upon completion of 20S proteasome maturation Structure: belongs to the PSMG2 family Compartment: nucleus (putative) Expression: - widely expressed - expressed in lung, brain & colon > muscle, stomach, spleen & heart > small intestine, pancreas & liver. Pathology: - highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue

General

chaperonin; chaperone nuclear protein

Properties

SIZE: entity length = 264 aa MW = 29 kD COMPARTMENT: cell nucleus

Database Correlations

UniProt Q969U7 Kegg hsa:5698

References

UniProt :accession Q969U7