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proteasome activator complex subunit 4 (proteasome activator PA200, PSME4, KIAA0077)
Function:
- activates proteasomal cleavage of peptides (energy- independent)
- role in spermatogenesis (putative)
- role in DNA repair (putative)
- interacts with the 20S & 26S proteasomes
- phosphorylated
Structure:
- homodimer
- contains 6 HEAT repeats
Compartment:
- nucleus, nuclear speckle
- found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H2O2
Alternative splicing: named isoforms=4
General
nuclear protein
phosphoprotein
protein subunit
Properties
SIZE: MW = 211 kD
entity length = 1843 aa
COMPARTMENT: cell nucleus
MOTIF: HEAT repeat {475-519}
HEAT repeat {998-1037}
HEAT repeat {1179-1217}
HEAT repeat {1354-1392}
HEAT repeat {1636-1674}
HEAT repeat {1680-1718}
Database Correlations
OMIM 607705
UniProt Q14997
Pfam PF02985
Kegg hsa:2319
References
UniProt :accession Q14997
Component-of
proteasome activator complex (PAC)