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protease nexin-2
Function:
- serine protease inhibitor
- derived from N-terminal end of APP-751
- with bound serine protease, it is internalized by LRP1
Interactions
molecular events
Related
CD91, low density lipoprotein (LDL) receptor related protein (LRP) 1, apolipoprotein E [apoE] receptor 1, chylomicron remnant receptor or alpha-2 macroglobulin receptor
General
protease nexin
Properties
COMPARTMENT: extracellular compartment
MOTIF: cysteine-rich region
sulfotyrosine site
MODIFICATION: sulfate
Zn+2-binding site
acidic region
MOTIF: acidic residue (SEVERAL)
Kunitz-type serine protease inhibitor [KPI] domain
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+0}
FOR-BINDING-OF: serine protease
binding site
FOR-BINDING-OF: heparan sulfate
binding site
FOR-BINDING-OF: collagenase-4
MOTIF: O-glycosylation site
N-glycosylation site (2)
SECRETED-BY: neuron
platelet
INHIBITS: coagulation factor XIa
References
- Rebeck GW et al
Association of membrane-bound amyloid precursor protein APP
with the apolipoprotein E receptor LRP.
Brain Res Mol Brain Res. 2001 Mar 5;87(2):238-45.
PMID: 11245926
Component-of
molecular complex