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glia-derived nexin; GDN; peptidase inhibitor 7; PI-7; protease nexin 1; PN-1; Serpin E2 (SERPINE2, PI7, PN1)
Function:
- serine protease inhibitor
- activity toward thrombin, trypsin, & urokinase
- promotes neurite extension by inhibiting thrombin
- binds heparin
Structure: belongs to the serpin family
Compartment: secreted, extracellular space
Alternative splicing: named isoforms=2
General
protease nexin
Properties
SIZE: entity length = 398 aa
MW = 44 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
N-glycosylation site {N118}
N-glycosylation site {N159}
peptide motif {365-366}
INHIBITS: serine protease
Database Correlations
OMIM 177010
UniProt P07093
Pfam PF00079
Entrez Gene 5270
Kegg hsa:5270
References
- UniProt :accession P07093
- Andrews BS.
Is the WKS motif the tissue-factor binding site for coagulation
factor VII?
Trends Biochem Sci. 1991 Jan;16(1):31-6. Review.
PMID: 2053135