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sperm protamine-P1; Cysteine-rich protamine (PRM1)
Function:
- protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis
- they compact sperm DNA into a highly condensed, stable & inactive complex
- cross-linked by interchain disulfide bonds around the DNA-helix
Structure: belongs to the protamine-P1 family
Compartment: nucleus
Expression: testis
General
protamine
Properties
SIZE: entity length = 51 aa
MW = 7 kD
COMPARTMENT: cell nucleus
CELL: spermatozoa
WITHIN: testis
MOTIF: cysteine residue {C6}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C39}
MODIFICATION: cysteine residue {C39}
cysteine residue {C40}
MODIFICATION: cysteine residue {C48}
cysteine residue {C48}
MODIFICATION: cysteine residue {C40}
Database Correlations
OMIM 182880
UniProt P04553
Pfam PF00260
Entrez Gene 5619
Kegg hsa:5619
References
- UniProt :accession P04553
- Entrez Gene :accession 5619