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beta-microseminoprotein; immunoglobulin-binding factor; IGBF; PN44; prostate secreted seminal plasma protein; prostate secretory protein of 94 amino acids; PSP-94; PSP94; seminal plasma beta-inhibin (MSMB, PRSP)
Function:
- interacts with PI16
- specific receptors for MSMB are found on spermatozoa & in the prostate
Structure:
- homodimer
- belongs to the beta-microseminoprotein family
Compartment: secreted, sperm surface
Alternative splicing: named isoforms=2; PSP94, PSP57
Expression:
- strongly expressed in prostate, liver, kidney, breast & penis
- also expressed in pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands & fallopian tube
- PSP94 is expressed in lung & breast
- PSP57 is found in kidney & bladder
Pathology:
- defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13
Note:
- originally thought to inhibit the secretion of FSH by pituitary cells
General
secreted protein
Properties
SIZE: entity length = 114 aa
MW = 13 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C22}
MODIFICATION: cysteine residue {C70}
cysteine residue {C38}
MODIFICATION: cysteine residue {C62}
cysteine residue {C57}
MODIFICATION: cysteine residue {C93}
cysteine residue {C60}
MODIFICATION: cysteine residue {C69}
cysteine residue {C62}
MODIFICATION: cysteine residue {C38}
cysteine residue {C69}
MODIFICATION: cysteine residue {C60}
cysteine residue {C70}
MODIFICATION: cysteine residue {C22}
cysteine residue {C84}
MODIFICATION: cysteine residue {C107}
cysteine residue {C93}
MODIFICATION: cysteine residue {C57}
cysteine residue {C107}
MODIFICATION: cysteine residue {C84}
Database Correlations
OMIM correlations
MORBIDMAP 157145
UniProt P08118
Pfam PF05825
Entrez Gene 4477
Kegg hsa:4477
References
UniProt :accession P08118